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  1. Summary of the Literature

    Studies indicate that the reversal of a temporary ileostomy can be safely performed early and no later than 12 weeks after creation. However, the latency between stoma creation and reversal is often significantly longer, up to 6 months, and not infrequently (9 - 57%) the reversal does not occur [1 - 4]. Reasons for a lack of reversal include advanced patient age, low body mass index, the presence of a terminal stoma, and neoadjuvant radiation therapy [2, 5, 6]. Other reasons include progression of the tumor disease, a primary procedure with complications, and particularly anastomotic insufficiency [1, 7].

    There are hardly any recommendations in the literature for the optimal timing of ileostomy reversal, resulting in considerable variation in practice among different clinics [8].

    In 2021, a high-evidence-level study was published examining postoperative complications after early reversal of a protective stoma (“early closure” [EC] ≤ 6 weeks vs. standard reversal (“standard closure” [SC] > 6 weeks) following rectal resection with an uneventful postoperative course [9]. Early reversal was not associated with a higher rate of postoperative complications. However, a prerequisite for early reversal is that patients do not undergo postoperative or adjuvant chemotherapy after the primary operation (rectal resection with protective stoma).

    Regarding anastomotic technique, hand-sewn and stapled anastomoses are equivalent in terms of morbidity. Stapled anastomoses are associated with shorter operation times and a lower rate of postoperative obstruction [10], but also with higher costs [11]. Comparing hand-sewn end-to-end anastomoses with side-to-end anastomoses, the end-to-end anastomosis leads to increased morbidity and length of hospital stay [12].

    The literature on skin closure after ileostomy reversal shows a significant advantage of purse-string suture over linear skin closure in terms of septic wound complications [13] with no differences in the rate of incisional hernias, operation duration, hospital stay, and patient quality of life [14].

    An interesting alternative to the purse-string suture is skin closure using the Gunsight technique.

  2. Currently ongoing studies on this topic

  3. Literature on this Topic

    1. Floodeen H, Lindgren R, Matthiessen P (2013) When are defunctioning stomas in rectal cancer surgery really reversed? Results from a population-based single center experience. Scand J Surg 102:246–250.

    2. David GG, Slavin JP, Willmott S, Corless DJ, Khan AU, Selvasekar CR (2010) Loop ileostomy following anterior resection: is it really temporary? Colorectal Dis 12:428–432.

    3. Gessler B, Haglind E, Angenete E (2012) Loop ileostomies in colorectal cancer patients—morbidity and risk factors for nonreversal. J Surg Res 178:708–714.

    4. Sier MF, van Gelder L, Ubbink DT, BemelmanWA, Oostenbroek RJ (2015) Factors affecting timing of closure and non-reversal of temporary ileostomies. Int J ColorectalDis 30:1185–1192.

    5. den Dulk M, Smit M, Peeters KCMJ, Kranenbarg EM-K, Rutten HJT, Wiggers T, Putter H, van de Velde CJH, Dutch Colorectal Cancer Group (2007) A multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study. Lancet Oncol 8:297–303.

    6. Lindgren R, Hallböök O, Rutegård J, Sjödahl R, Matthiessen P (2011) What is the risk for a permanent stoma after low anterior resection of the rectum for cancer? A six-year follow-up of a multicenter trial. Dis Colon Rectum 54:41–47.

    7. Mohammed Ilyas MI, Haggstrom DA, Maggard-Gibbons MA, Wendel CS, Rawl S, Schmidt CM, Ko CY, Krouse RS (2018) Patients with temporary ostomies: veterans administration hospitals multiinstitutional retrospective study. JWound Ostomy Continence Nurs 45:510–515.

    8. Ostomy Guidelines Task Force, Goldberg M, Aukett LK, Carmel J, Fellows J, Folkedahl B, Pittman J, Palmer R (2010) Management of the patient with a fecalostomy: best practice guideline for clinicians. J Wound Ostomy Continence Nurs 37:596–598.

    9. Clausen FB et al (2021) Safety of early ileostomy closure: a systematic review and metaanalysis of randomized controlled trials. Int J Colorect Dis 36(2):203–212.

    10. Löffler T, Rossion I, Bruckner T, Diener MK, Koch M, von Frankenberg M, Pochhammer J, Thomusch O, Kijak T, Simon T, Mihaljevic AL, Krüger M, Stein E, Prechtl G, Hodina R, Michal W, Strunk R, Henkel K, Bunse J, Jaschke G, Politt D, Heistermann HP, Fußer M, Lange C, Stamm A, Vosschulte A, Holzer R, Partecke LI, Burdzik E, Hug HM, Luntz SP, Kieser M, Büchler MW, Weitz J, HASTA Trial Group (2012) HAnd Suture Versus STApling for Closure of Loop Ileostomy (HASTA Trial): results of a multicenter randomized trial (DRKS00000040). Ann Surg 256:828–835.

    11. Nemeth ZH, Bogdanovski DA, Hicks AS, Paglinco SR, Sawhney R, Pilip SA, Stopper PB, Rolandelli RH (2018) Outcome and cost analysis of hand-sewn and stapled anastomoses in the reversal of loop Ileostomy. AmSurg84:615–619.

    12. Prassas D, Ntolia A, Spiekermann J-D, Rolfs T-M, Schumacher F-J (2018) Reversal of diverting loop Ileostomy using hand-sewn side-to-side versus end-to-end anastomosis after low anterior resection for rectal cancer: a single center experience. AmSurg84:1741–1744.

    13. Gachabayov M, Lee H, Chudner A, Dyatlov A, Zhang N, Bergamaschi R (2019) Purse-string vs. linear skin closure at loop ileostomy reversal: a systematic review and meta-analysis. Tech Coloproctol 23:207–220.

    14. Rausa E, Kelly ME, Sgroi G, Lazzari V, Aiolfi A, Cavalcoli F, Bonitta G, Bonavina L (2019) Quality of life following ostomy reversal with purse-string vs linear skin closure: a systematic review. Int J Colorectal Dis 34:209–216.

  4. Reviews

    1. O'Sullivan NJ, Temperley HC, Nugent TS, Low EZ, Kavanagh DO, Larkin JO, Mehigan BJ, McCormick PH, Kelly ME. Early vs. standard reversal ileostomy: a systematic review and meta-analysis. Tech Coloproctol. 2022 May 21.

    2. Podda M, Coccolini F, Gerardi C, Castellini G, Wilson MSJ, Sartelli M, Pacella D, Catena F, Peltrini R, Bracale U, Pisanu A. Early versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a meta-analysis and trial sequential analysis of safety and functional outcomes. Int J Colorectal Dis. 2022 Apr;37(4):737-756.

    3. Turner GA, Clifford KA, Holloway R, Woodfield JC, Thompson-Fawcett M. The impact of prolonged delay to loop ileostomy closure on postoperative morbidity and hospital stay: A retrospective cohort study. Colorectal Dis. 2022 Jul;24(7):854-861.

    4. Vogel I, Reeves N, Tanis PJ, Bemelman WA, Torkington J, Hompes R, Cornish JA. Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis. Tech Coloproctol. 2021 Jul;25(7):751-760.

    5. Peltrini R, Imperatore N, Altieri G, Castiglioni S, Di Nuzzo MM, Grimaldi L, D'Ambra M, Lionetti R, Bracale U, Corcione F. Prevention of incisional hernia at the site of stoma closure with different reinforcing mesh types: a systematic review and meta-analysis. Hernia. 2021 Jun;25(3):639-648.

    6. Cheng Z, Dong S, Bi D, Wang Y, Dai Y, Zhang X. Early Versus Late Preventive Ileostomy Closure Following Colorectal Surgery: Systematic Review and Meta-analysis With Trial Sequential Analysis of Randomized Controlled Trials. Dis Colon Rectum. 2021 Jan;64(1):128-137.

    7. Clausen FB, Dohrn N, Hölmich ER, Klein M, Gögenur I. Safety of early ileostomy closure: a systematic review and meta-analysis of randomized controlled trials. Int J Colorectal Dis. 2021 Feb;36(2):203-212.

    8. Aljorfi AA, Alkhamis AH. A Systematic Review of Early versus Late Closure of Loop Ileostomy. Surg Res Pract. 2020 Aug 31;2020:9876527.

    9. Wang L, Chen X, Liao C, Wu Q, Luo H, Yi F, Wei Y, Zhang W. Early versus late closure of temporary ileostomy after rectal cancer surgery: a meta-analysis. Surg Today. 2021 Apr;51(4):463-471.

    10. Ng ZQ, Levitt M, Platell C. The feasibility and safety of early ileostomy reversal: a systematic review and meta-analysis. ANZ J Surg. 2020 Sep;90(9):1580-1587.

    11. De Haes F, Bullen NL, Antoniou GA, Smart NJ, Antoniou SA. Systematic review and meta-analysis of incisional hernia post-reversal of ileostomy. Hernia. 2020 Feb;24(1):9-21.

  5. Guidelines

    none

  6. literature search

    Literature search on the pages of pubmed.