Start your free 3-day trial — no credit card required, full access included

Evidence - Anastomosis technique, biliodigestive, according to Hepp-Couinaud

  1. Summary of the Literature

    The hepatico-jejunostomy end-to-side with a Roux-Y excluded upper jejunal loop represents the gold standard of biliodigestive anastomosis.

    The success of hepatobiliary anastomoses is influenced by the diameter of the bile duct and the section to be anastomosed. Also crucial is whether it is a primary or revision procedure, and whether there are accompanying infections of the bile ducts. Accurate preoperative diagnostics of the biliary anatomy are indispensable for complication-free biliary surgery. Regarding the reconstructive procedures, hepatico-jejunostomy has established itself as the standard. Here, the biliodigestive anastomosis is preferably placed above the cystic duct exit and about 2–3 cm below the hepatic bifurcation.

    The rationale for this height specification lies in the arterial perfusion of the common bile duct (CBD). Thus, a short stump is better arterially supplied than a long one. Diathermy should be used very cautiously due to tissue necrosis. Bleeding at the CBD should therefore be managed with fine transfixion ligatures.

    In the suturing of the biliodigestive anastomosis with single button sutures, a peculiarity is that the knots may partially lie in the lumen. Before completing the anterior wall suture, the patency of the anastomosis should be checked in all cases (e.g., using an Overholt clamp).

    With single button sutures, the insufficiency rate appears increased, whereas with continuous sutures, the stenosis rate rises. However, there are no randomized studies on this issue (single button suture or continuous suture?).

    The anastomosis should be performed with thin, absorbable, monofilament suture material (PDS of size 5/0 or 6/0).

    Simultaneous injuries to the common hepatic duct (CHD) and the right hepatic artery are associated with a significantly higher insufficiency rate after hepatico-jejunostomy.

    The creation of a so-called "inspection stoma" in the sense of a modified Roux-en-Y hepaticojejunostomy offers the possibility of performing endoscopic and radiological controls after bile duct resections. Indications for this are complex bile duct injuries, tumor resections with uncertain tumor-free resection margins, as well as recurrent intrahepatic sludge formation or cholelithiasis.

    In malignant bile duct stenosis, the biliodigestive anastomosis, due to today's low complication and mortality rates, especially in patients in good general condition and without manifest distant metastasis, represents a highly efficient palliative therapy. The secure prevention of duodenal obstruction through simultaneous creation of a gastroenterostomy and long-term free bile drainage can offer advantages over endoscopic procedures, especially in patients with a survival probability of over six months. However, the decisive factor is the interplay of surgical and endoscopic therapeutic options to achieve the optimal palliative therapy for each individual patient.

    Due to the postoperatively altered anatomy (endoscopic access to the biliodigestive anastomosis is only possible via the footpoint anastomosis!), the rate of conventionally endoscopically successfully performed ERCP is comparatively low. Single-balloon enteroscopy presents a promising and low-complication alternative here. With appropriate expertise, the use of SBE-assisted ERCP can avoid more invasive procedures such as PTC or surgical intervention.

  2. Currently ongoing studies on this topic

  3. Literature on this Topic

    Goumard C, Boleslawski E, Brustia R, Dondero F, Herrero A, Lesurtel M, Barbier L, Lecolle K, Soubrane O, Bouyabrine H, Mabrut JY, Salamé E, Cachanado M, Simon T, Scatton O. Duct-to-duct biliary reconstruction with or without an intraductal removable stent in liver transplantation: The BILIDRAIN-T multicentric randomised trial. JHEP Rep. 2022 Jul 6;4(10):100530

    Le Bot A, Sokal A, Choquet A, Maire F, Fantin B, Sauvanet A, de Lastours V. Clinical and microbiological characteristics of reflux cholangitis following bilio-enteric anastomosis. Eur J Clin Microbiol Infect Dis. 2022 Aug;41(8):1139-1143.

    Martinino A, Pereira JPS, Spoletini G, Treglia G, Agnes S, Giovinazzo F. The use of the T-tube in biliary tract reconstruction during orthotopic liver transplantation: An umbrella review. Transplant Rev (Orlando). 2022 Jul 7;36(4):100711.

    Calamia S, Barbara M, Cipolla C, Grassi N, Pantuso G, Li Petri S, Pagano D, Gruttadauria S. Risk factors for bile leakage after liver resection for neoplastic disease. Updates Surg. 2022 Oct;74(5):1581-1587.

    Ödemiş B, Başpınar B, Durak MB, Coşkun O, Torun S. Lumen reconstruction with magnetic compression anastomosis technique in a patient with complete esophageal stricture. Acta Gastroenterol Belg. 2022 Apr-Jun;85(2):393-395.

    Vest M, Ciobanu C, Nyabera A, Williams J, Marck M, Landry I, Sumbly V, Iqbal S, Shah D, Nassar M, Nso N, Rizzo V. Biliary Anastomosis Using T-tube Versus No T-tube for Liver Transplantation in Adults: A Review of Literature. Cureus. 2022 Apr 18;14(4):e24253.

    Yamaguchi N, Matsuyama R, Kikuchi Y, Sato S, Yabushita Y, Sawada Y, Homma Y, Kumamoto T, Takeda K, Morioka D, Endo I, Shimada H. Role of the Intramural Vascular Network of the Extrahepatic Bile Duct for the Blood Circulation in the Recipient Extrahepatic Bile Duct Used for Duct-to-Duct-Biliary-Anastomosis in Living Donor Liver Transplantation. Transpl Int. 2022 May 3;35:10276.

    Kim MS, Hong SK, Woo HY, Cho JH, Lee JM, Yoon KC, Choi Y, Yi NJ, Lee KW, Suh KS. Optimal Intervention for Initial Treatment of Anastomotic Biliary Complications After Right Lobe Living Donor Liver Transplantation. Transpl Int. 2022 Apr22;35:10044.

    Lee IJ, Lee JH, Kim SH, Woo SM, Lee WJ, Kang B, Kim HB. Percutaneous transhepatic treatment for biliary stricture after duct-to-duct biliary anastomosis in living donor liver transplantation: a 9-year single-center experience. Eur Radiol. 2022 Apr;32(4):2414-2425.

    Fasullo M, Kandakatla P, Amerinasab R, Kohli DR, Shah T, Patel S, Bhati C, Bouhaidar D, Siddiqui MS, Vachhani R. Early laboratory values after liver transplantation are associated with anastomotic biliary strictures. Ann Hepatobiliary Pancreat Surg. 2022 Feb 28;26(1):76-83.

    Ma D, Liu P, Lan J, Chen B, Gu Y, Li Y, Yue P, Liu Z, Guo D. A Novel End-to-End Biliary-to-Biliary Anastomosis Technique for Iatrogenic Bile Duct Injury of Strasberg-Bismuth E1-4 Treatment: A Retrospective Study and in vivo Assessment. Front Surg. 2021 Oct 28;8:747304.

    Horacio J. Asbun, Asbun HJ. The SAGES Manual of Biliary Surgery. Cham: Springer International Publishing AG; 2020.

    Lillemoe KD, Jarnagin W. Hepatobiliary and Pancreatic Surgery. Philadelphia: Wolters Kluwer Health; 2013.

    Jarnagin W. Blumgart's surgery of the liver, biliary tract, and pancreas, 6th ed. Philadelphia, PA: Elsevier; 2017.

  4. Reviews

    Ai C, Wu Y, Xie X, Wang Q, Xiang B. Roux-en-Y hepaticojejunostomy or hepaticoduodenostomy for biliary reconstruction after resection of congenital biliary dilatation: a systematic review and meta-analysis. Surg Today. 2023 Jan;53(1):1-11.

    Alvanos A, Rademacher S, Hoffmeister A, Seehofer D. Surgical approach to benign bile duct alterations. Chirurg. 2020 Jan;91(1):11-17.

    Bednarsch J, Trauwein C, Neumann UP, Ulmer TF. Complication management after bile duct surgery. Chirurg. 2020 Jan;91(1):29-36.

    Birgin E, Téoule P, Galata C, Rahbari NN, Reissfelder C. Cholangitis following biliary-enteric anastomosis: A systematic review and meta-analysis. Pancreatology. 2020 Jun;20(4):736-745.

    Cubisino A, Dreifuss NH, Cassese G, Bianco FM, Panaro F. Minimally invasive biliary anastomosis after iatrogenic bile duct injury: a systematic review. Updates Surg. 2023 Jan;75(1):31-39.

    Elkomos BE, Abdelaal A. Do We Need to Use a Stent in Biliary Reconstruction to Decrease the Incidence of Biliary Complications in Liver Transplantation? A Systematic Review and Meta-Analysis. J Gastrointest Surg. 2023 Jan;27(1):180-196.

    Hajibandeh S, Hajibandeh S, Parente A, Bartlett D, Chatzizacharias N, Dasari BVM, Hartog H, Perera MTPR, Marudanayagam R, Sutcliffe RP, Roberts KJ, Isaac JR, Mirza DF. Meta-analysis of interrupted versus continuous suturing for Roux-en-Y hepaticojejunostomy and duct-to-duct choledochocholedochostomy. Langenbecks Arch Surg. 2022 Aug;407(5):1817-1829.

    Hinojosa-Gonzalez DE, Roblesgil-Medrano A, Leon SUV, Espadas-Conde MA, Flores-Villalba E. Biliary reconstruction after choledochal cyst resection: a systematic review and meta-analysis on hepaticojejunostomy vs hepaticoduodenostomy. Pediatr Surg Int. 2021 Oct;37(10):1313-1322.

    Kambakamba P, Cremen S, Möckli B, Linecker M. Timing of surgical repair of bile duct injuries after laparoscopic cholecystectomy: A systematic review. World J Hepatol. 2022 Feb 27;14(2):442-455.

    Martinino A, Pereira JPS, Spoletini G, Treglia G, Agnes S, Giovinazzo F. The use of the T-tube in biliary tract reconstruction during orthotopic liver transplantation: An umbrella review. Transplant Rev (Orlando). 2022 Jul7;36(4):100711.

    Schreuder AM, Nunez Vas BC, Booij KAC, van Dieren S, Besselink MG, Busch OR, van Gulik TM. Optimal timing for surgical reconstruction of bile duct injury: meta-analysis. BJS Open. 2020 Oct;4(5):776-786.

    Vaska AI, Abbas S. The role of bile leak testing in liver resection: a systematic review and meta-analysis. HPB (Oxford). 2019 Feb;21(2):148-156.

    Vest M, Ciobanu C, Nyabera A, Williams J, Marck M, Landry I, Sumbly V, Iqbal S, Shah D, Nassar M, Nso N, Rizzo V. Biliary Anastomosis Using T-tube Versus No T-tube for Liver Transplantation in Adults: A Review of Literature. Cureus. 2022 Apr 18;14(4):e24253

  5. Guidelines

    Currently none

  6. literature search

    Literature search on the pages of pubmed.