Evidence - Anal fistula, closure with Anal Fistula Plug® (AFP®)

  1. Summary of the Literature

    Originating from the USA, the Anal Fistula Plug® was introduced in Germany in 2006. Using a narrow cylinder made from porcine collagen, the fistula tract is occluded from the inside. Unlike other surgical techniques, extensive removal of fistula tissue is avoided, simplifying the operation and resulting in only small postoperative wounds. Initially, very enthusiastic reports claimed healing rates of over 85%, but randomized studies have only achieved healing rates of 20-30%. Therefore, the plug is now used only in a few cases as one of several options for high fistulas.

  2. Currently ongoing studies on this topic

  3. Literature on this topic

    1. Johnson E, Janette U, Gaw J, Armstrong DN: Efficacy of Anal fistula plug vs. fibrin glue in closure of anorectal fistulas; Dis Colon Rectum 2006; 49: 371-376
    2. O´Connor L, Champagne BJ, Ferguson MA, Orangio GR, Schertzer ME, Armstrong DN: Efficacy of Anal Fistula Plug in Closure of Crohn´s Anorectal Fistulas; Dis Colon Rectum 2006; 49: 1569–1573
    3. Champagne BJ, O´Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN: Efficacy of Anal Fistula Plug in Closure of Cryptoglandular Fistulas: Long-Term Follow-Up; Dis Colon Rectum 2006; 49: 1817–1821
    4. Ellis CN: Bioprosthetic Plugs for Complex Anal Fistulas: An Early Experience Journal of Surgical Education 2007; 64: 36-40
    5. Van Koperen P, Hoore A, Wolthuis A et al.: Anal Fistula Plug for Closure of Difficult Anorectal Fistula: A Prospective Study; Dis Colon Rectum 2007; 50: 2168–2172.
    6. Schwandner O, Stadler F, Dietl O, Wirsching RP, Fuerst A: Initial experience on efficacy in closure of cryptoglandular and Crohn’s transsphincteric fistulas by the use of the anal fistula plug; Int J Colorectal Dis 2008; 23:319–324
    7. Ortiz H, Marzo J, Ciga MA, Oteiza F, Armendariz P, deMiguel M (2009) Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano. Br J Surg 96:608-612
Reviews

Iqbal N, Shah R, Alrubaiy L, Tozer P. Do Patient-Reported Quality-of-Life (QoL) Scales Provide an A

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