Evidence - Gastrectomy

  1. Literature summary

    • The extent of the resection can already be planned before surgery based on the histomorphological  Laurén classification (1, 2).
    • In adenocarcinoma of the gastroesophageal junction (AEG II/III), particularly in locally advanced tumors and following preoperative chemotherapy, frozen section of the proximal resection margin should be obtained (5).
    • Resection of an adequate number of lymph nodes, even if benign, (7) may be beneficial.
    • At present, the lack of randomized trials does not allow assessment of the role of laparoscopic resection (1, 3).
    • The postulated benefits of preserving duodenal transit have not been proven. Pouch formation/gastric replacement is advocated, although few meaningful trials are available (2).
  2. Ongoing trials on this topic

  3. References on this topic

    1.  
      1. Brennan MF (2005): Current status of surgery for gastric cancer: a review. Gastric Cancer 8:64-70
      2. Chin AC, Espat NJ (2003): Total gastrectomy: options for restoration of gastrointestinal conituitiy. Lancet Oncol 4:271-276
      3. Huscher CG, Mingoli A, Szarzini G et al. (2007): Totally laparoscopic total and subtotal gastrectomy with extended lymph node dissection for early and advanced gastric cancer: early and long-term results of a 100-patient series. Am J Surg 194:839-844
      4. Lehnert T, Buhl K (2004): Techniques of reconstruction after total gastectomy for cancer. Br J Surg 91:528-539
      5. Meyer HJ, Opitz G (2007): Aktuelle chirurgische Therapiestrategien beim Magenkarzinom. Verdauungskrankheiten 25:112-121
      6. Mönig SP, Lübke T, Baldus SE (2005): Primärtherapie des Magenkarzinoms. Onkologe 11:630-639
      7. Siewert JR, Kestlmeier R, Busch R et al. (1996): Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases. Br J Surg 83:1144-1147
  4. Reviews

    Merga ZC, Lee JS, Gong CS. Outcomes of Gastrectomy for Gastric Cancer in Patients Aged >80 Years: A Systematic Literature Review and Meta-Analysis. J Gastric Cancer. 2023 Jul;23(3):428-450.

    Heng W, Lye JYT, Lee ZJ, Chan WH, Tan JTH. Laparoscopic completion gastrectomy: A single-institution case series and systematic review of the literature. Asian J Endosc Surg. 2023 Jul 31.

    Salavatizadeh M, Soltanieh S, Radkhah N, Ataei Kachouei AH, Bahrami A, Khalesi S, Hejazi E. The association between skeletal muscle mass index (SMI) and survival after gastrectomy: A systematic review and meta-analysis of cohort studies. Eur J Surg Oncol. 2023 Jul 6:106980.

    Aiolfi A, Sozzi A, Bonitta G, Lombardo F, Cavalli M, Campanelli G, Bonavina L, Bona D. Short-term outcomes of different esophagojejunal anastomotic techniques during laparoscopic total gastrectomy: a network meta-analysis. Surg Endosc. 2023 Aug;37(8):5777-5790.

  5. Guidelines

  6. literature search

    Literature search on the pages of pubmed.