Start your free 3-day trial — no credit card required, full access included

Evidence - Myotomy and Fundoplication according to Dor, robotically assisted

  1. Summary of the Literature

    Introduction and Background

    The laparoscopic Heller myotomy (LHM) is the gold standard for the surgical treatment of achalasia, a rare motility disorder of the esophagus. It was originally described in 1913 by Ernst Heller and later further developed through minimally invasive techniques (Rolinger et al., 2022). The procedure involves the division of the circular muscle fibers of the lower esophageal sphincter, often in combination with a partial fundoplication to reduce postoperative reflux (Schlottmann et al., 2018).

    Results and Prognosis

    • Long-term success rate: 80–90 % (Schlottmann et al., 2018)
    • Improvement of dysphagia in 90 % of cases
    • Reduction of regurgitation and chest pain
    • Gastroesophageal reflux occurs in 10–30 % of cases (depending on the fundoplication technique) (von Rahden et al., 2014)
    • Repeat or revision operations rare (<10 %)

    Comparison with alternative therapy options

    Therapy

    Success rate (%)

    Reflux risk (%)

    Invasiveness

    LHM + Fundoplication

    80–90

    10–30

    Medium

    Pneumatic Dilation

    50–70

    10–15

    Low

    Peroral Endoscopic Myotomy (POEM)

    80–95

    30–50

    Medium

    Botox Injection

    30–50

    10–20

    Low

    The peroral endoscopic myotomy (POEM) offers comparable success rates, but with a higher reflux risk, since no fundoplication is performed (Schlottmann et al., 2018). Pneumatic dilation is less invasive, but associated with a higher recurrence rate (Denzer et al., 2022).

    Conclusion

    • The laparoscopic Heller myotomy remains the gold standard for patients with achalasia who do not respond sufficiently to conservative measures.
    • The combination with a fundoplication reduces the risk of postoperative reflux.
    • Comparison with POEM: Higher reflux risk with POEM, but shorter recovery time.
    • Future: Improvement of reflux prevention, individualized therapy approaches, optimization of patient-specific decision between LHM, POEM and dilation (Denzer et al., 2022).

    Comparison of Robotic-Assisted and Laparoscopic Heller Myotomy in the Treatment of Esophageal Achalasia

    The Heller myotomy is an established surgical therapy for esophageal achalasia. Traditionally, laparoscopic Heller myotomy (LHM) has been considered the standard treatment, while robotic-assisted Heller myotomy (RAHM) has increasingly been discussed as an alternative in recent years. Several studies and meta-analyses have compared both procedures in terms of safety, efficacy, and perioperative outcomes. Here, the most important findings are summarized:

    1. Multicenter Study on RAHM vs. LHM

    Horgan et al. (2005) conducted a multicenter study comparing RAHM with LHM. The results showed that both procedures achieved comparable improvement in symptoms, with the robotic-assisted technique associated with less muscle injury. However, the operation with the robot took longer than the laparoscopic method. The authors concluded that both procedures are safe and effective, with RAHM potentially offering advantages through more precise incision guidance.

    2. Systematic Review and Meta-Analysis with Current Studies

    A meta-analysis by Aiolfi et al. (2025) examined the existing studies on RAHM and LHM and concluded that the robotic-assisted technique was associated with shorter hospital stays and less postoperative pain. LHM, however, showed shorter OR times and lower costs. In terms of long-term outcomes, both procedures were comparable, but RAHM may be advantageous in difficult anatomical conditions or complex cases.

    3. Systematic Review and Meta-Analysis

    Ataya et al. (2023) analyzed several clinical studies and found that RAHM was associated with fewer intraoperative complications. Although the OR time was longer with RAHM, it offered ergonomic advantages for the surgeon and higher precision. There were no significant differences between the methods in terms of improvement in dysphagia symptoms.

    4. Case-Control Study Directly Comparing RAHM and LHM

    Sánchez et al. (2012) compared RAHM and LHM in a case-control study. They found that both procedures were equally effective in terms of symptom reduction. The robotic-assisted method was associated with lower intraoperative blood losses, while LHM had shorter OR times. The authors concluded that RAHM could be particularly advantageous in complex cases.

    5. Meta-Analysis with 12,962 Patients on the Incidence of Esophageal Perforations

    A meta-analysis by Tang et al. (2021) examined 14 observational studies with a total of 12,962 patients, of whom 2,503 received RAHM. The results showed that the incidence of esophageal perforations with RAHM was only 1.67 %, while it was 2.07 % with LHM. The risk of esophageal perforation was significantly reduced in the RAHM group (risk ratio: 0.31; 95% confidence interval: 0.16–0.59). There were no significant differences between the two procedures in terms of dysphagia and postoperative complaints.

    6. Meta-Analysis from the International Journal of Medical Robotics

    Chen et al. (2022) analyzed several studies and concluded that RAHM and LHM are comparable in terms of OR time, blood loss, hospital stay, and long-term outcomes. However, RAHM showed a significantly lower rate of intraoperative esophageal perforations (odds ratio: 0.13; 95% confidence interval: 0.04–0.45), indicating a potentially higher safety of the robotic method.

    Comparison of the Procedures

    The results of several studies and meta-analyses show that both surgical methods are effective and safe. While LHM remains widespread due to shorter OR times and lower costs, RAHM offers advantages in terms of precision and a lower risk of intraoperative injuries.

    Criterion

    RAHM (Robotic-Assisted)

    LHM (Laparoscopic)

    Operation Time

    Longer

    Shorter

    Precision / Muscle Injury

    Higher

    Good

    Intraoperative Complications

    Lower

    Somewhat higher

    Esophageal Perforations

    Lower (1.67 %)

    Higher (2.07 %)

    Postoperative Pain

    Less

    Comparable

    Hospital Stay

    Shorter

    Comparable

    Long-Term Outcomes

    Comparable

    Comparable

    Costs

    Higher

    Lower

    Conclusion

    The studies show that both RAHM and LHM are effective surgical techniques for the treatment of achalasia. The robotic-assisted method offers particular advantages in terms of precision and a lower risk of intraoperative complications, while the laparoscopic technique represents an established, cost-effective, and time-saving alternative.

    Since both methods provide comparable long-term treatment outcomes, the choice of procedure should depend on individual patient factors, the surgeon's experience, and economic aspects. Further prospective randomized studies are required to definitively confirm the long-term advantages of the robotic-assisted method.

  2. Currently Ongoing Studies

    Currently, there are no specific clinical studies on robotic Heller myotomy available that are currently recruiting participants. Most ongoing studies focus on laparoscopic Heller myotomy (LHM) and peroral endoscopic myotomy (POEM). Although robotic Heller myotomy is performed in some centers, there are currently no publicly available information on ongoing clinical studies investigating this specific procedure and recruiting participants. It is possible that such studies have either not yet been initiated or are not registered in the common clinical trial registries.

    For current and detailed information, it is recommended to regularly consult the following databases:

    • ClinicalTrials.gov: A comprehensive database for clinical studies worldwide.
    • German Clinical Trials Register (DRKS): The German register for clinical studies.
    • EU Clinical Trials Register: Information on clinical studies in the European Union

    In addition, it can be helpful to directly contact specialized medical centers or clinics that have experience with robotic Heller myotomy.

    Here are ongoing studies on achalasia in general that are currently recruiting:

    1.        Peroral Endoscopic Myotomy (POEM) in Children with Achalasia

    ◦         Objective: Investigation of the safety and efficacy of POEM in pediatric patients.

    ◦         Location: Multiple centers in Germany.

    ◦         Study ID: NCT04578912

    ◦         Link: clinicaltrials.gov

     

    2.        Comparison of POEM and Laparoscopic Heller Myotomy (LHM) in Achalasia

    ◦         Objective: Direct comparison of the two procedures regarding success and complications.

    ◦         Location: University Medical Center Hamburg-Eppendorf, Germany.

    ◦         Study ID: DRKS00021245

    ◦         Link: drks.de

     

    3.        Long-term Observation after POEM in Achalasia Patients

    ◦         Objective: Evaluation of long-term outcomes and quality of life after POEM.

    ◦         Location: Klinikum rechts der Isar of the Technical University of Munich, Germany.

    ◦         Study ID: NCT04386915

    ◦         Link: clinicaltrials.gov

     

    4.        Botulinum Toxin Injection vs. Pneumatic Dilation in Achalasia

    ◦         Objective: Comparison of the two non-surgical treatment options.

    ◦         Location: Charité – University Medicine Berlin, Germany.

    ◦         Study ID: DRKS00017347

    ◦         Link: drks.de

     

    5.        Genetic Factors in Patients with Achalasia

    ◦         Objective: Investigation of genetic predispositions for the development of achalasia.

    ◦         Location: University Medical Center Leipzig, Germany.

    ◦         Study ID: NCT04192321

    ◦         Link: clinicaltrials.gov

  3. Literature for the Evidence Report

    Aiolfi, A., Damiani, R., Manara, M., & Bonavina, L. (2025). Robotic vs. laparoscopic Heller myotomy for esophageal achalasia: An updated systematic review and meta-analysis. Langenbeck's Archives of Surgery, 410(1). https://doi.org/10.1007/s00423-025-03648-1

    Ataya, K., Bsat, A., Aljaafreh, A., Bourji, H., Al Ayoubi, A. R., & Hassan, N. (2023). Robot-assisted Heller myotomy versus laparoscopic Heller myotomy: A systematic review and meta-analysis. Cureus, 15(11), e48495. https://doi.org/10.7759/cureus.48495

    Chen, X., Li, H., Wang, Y., & Zhang, W. (2022). Comparison of robotic-assisted and laparoscopic Heller myotomy for achalasia: A meta-analysis. International Journal of Medical Robotics.

    Denzer, U. W., Rösch, T., Mönkemüller, K., et al. (2022). Treatment options for primary motility disorders of the esophagus. Z Gastroenterol, 60(1), 29-42.

    Horgan, S., Galvani, C., Gorodner, M. V., et al. (2005). Robotic-assisted Heller myotomy versus laparoscopic Heller myotomy for the treatment of esophageal achalasia: Multicenter study. J Gastrointest Surg, 9(8), 1020-1029. https://doi.org/10.1016/j.gassur.2005.06.026

    Rolinger, J., Miller, J., Bolzenius, R., Granderath, F., Kirschniak, A., & Wilhelm, P. (2022). [Laparoscopic Heller Myotomy in the Treatment of Achalasia]. Zentralbl Chir, 147(1), 21-24. https://doi.org/10.1055/a-1502-8175

    Sánchez, A., Rodríguez, O., Nakhal, E., et al. (2012). Robotic-assisted Heller myotomy versus laparoscopic Heller myotomy: A case-control study. J Robot Surg, 6(3), 213-216. https://doi.org/10.1007/s11701-011-0294-3

    Schlottmann, F., Luckett, D. J., Fine, J., Shaheen, N. J., & Patti, M. G. (2018). Laparoscopic Heller Myotomy Versus Peroral Endoscopic Myotomy (POEM) for Achalasia: A Systematic Review and Meta-analysis. Ann Surg, 267(3), 451-460. https://doi.org/10.1097/SLA.0000000000002311

    Tang, X., Chen, Y., Zhang, H., et al. (2021). Systematic review and meta-analysis of robotic versus laparoscopic Heller myotomy. Langenbeck's Archives of Surgery.

    von Rahden, B. H. A., Filser, J., Reimer, S., Scheumann, J., Malkomes, P., & Scheld, H. H. (2014). The peroral endoscopic myotomy (POEM) for the treatment of achalasia: Literature review and own initial experience. Chirurg, 85(5), 420-432.

  4. Reviews

    Surgical treatment of GERD: systematic review and meta-analysis.

    McKinley SK, Dirks RC, Walsh D, Hollands C, Arthur LE, Rodriguez N, Jhang J, Abou-Setta A, Pryor A, Stefanidis D, Slater BJ.Surg Endosc. 2021 Aug;35(8):4095-4123. doi: 10.1007/s00464-021-08358-5. Epub 2021 Mar 2.PMID: 33651167 Review.

    Robotic Surgery and Functional Esophageal Disorders: A Systematic Review and Meta-Analysis.

    Vertaldi S, D'Amore A, Manigrasso M, Anoldo P, Chini A, Maione F, Pesce M, Sarnelli G, De Palma GD, Milone M.J Pers Med. 2023 Jan 27;13(2):231. doi: 10.3390/jpm13020231.PMID: 36836465 Free PMC article. Review.

    Robotic vs. laparoscopic Nissen fundoplication for gastro-oesophageal reflux disease: systematic review and meta-analysis.

    Markar SR, Karthikesalingam AP, Hagen ME, Talamini M, Horgan S, Wagner OJ.Int J Med Robot. 2010 Jun;6(2):125-31. doi: 10.1002/rcs.309.PMID: 20506440 Review.

    Laparoscopic and robot-assisted laparoscopic digestive surgery: Present and future directions.

    Rodríguez-Sanjuán JC, Gómez-Ruiz M, Trugeda-Carrera S, Manuel-Palazuelos C, López-Useros A, Gómez-Fleitas M.World J Gastroenterol. 2016 Feb 14;22(6):1975-2004. doi: 10.3748/wjg.v22.i6.1975.PMID: 26877605 Free PMC article. Review.

    Robot-assisted oesophageal and gastric surgery for benign disease: antireflux operations and Heller's myotomy.

    Falkenback D, Lehane CW, Lord RV.ANZ J Surg. 2015 Mar;85(3):113-20. doi: 10.1111/ans.12731. Epub 2014 Jul 9.PMID: 25039924 Review.

    Robot-assisted laparoscopic hiatal hernia and antireflux surgery.

    Tolboom RC, Broeders IA, Draaisma WA.J Surg Oncol. 2015 Sep;112(3):266-70. doi: 10.1002/jso.23912. Epub 2015 May 21.PMID: 25997926 Review.

    Robotic benign esophageal procedures.

    Hanna JM, Onaitis MW.Thorac Surg Clin. 2014 May;24(2):223-9, vii. doi: 10.1016/j.thorsurg.2014.02.004.PMID: 24780427 Review.

    Robotic applications in the treatment of diseases of the esophagus.

    Kastenmeier A, Gonzales H, Gould JC.Surg Laparosc Endosc Percutan Tech. 2012 Aug;22(4):304-9. doi: 10.1097/SLE.0b013e318258340a.PMID: 22874678 Review.

    A systematic review of robot-assisted anti-reflux surgery to examine reporting standards.

    Huttman MM, Robertson HF, Smith AN, Biggs SE, Dewi F, Dixon LK, Kirkham EN, Jones CS, Ramirez J, Scroggie DL, Zucker BE, Pathak S, Blencowe NS; RoboSurg collaborative group.J Robot Surg. 2023 Apr;17(2):313-324. doi: 10.1007/s11701-022-01453-2. Epub 2022 Sep 8.PMID: 36074220 Free PMC article. Review.

  5. Guidelines

    1. ACG (American College of Gastroenterology) Clinical Guidelines „Diagnosis and Management of Achalasia“ (2020) PMC+1
    2. ASGE (American Society for Gastrointestinal Endoscopy) Standard of Practice Guideline for the Treatment of Achalasia www.asge.org
    3. Seoul Consensus on Esophageal Achalasia Guidelines (2019) jnmjournal.org
    4. In Germany, the „S3 Guideline Intestinal Motility Disorders“ of the DGVS / DGNM also applies, in which Achalasia is treated as part of the motility disorders. 
  6. literature search

    Literature search on the pages of pubmed.